Reevaluation of the origin of CD44high "memory phenotype" CD8 T cells: comparison between memory CD8 T cells and thymus-independent CD8 T cells

Activated Primary and Memory CD8 T Cells

Memory CD8+ T cells require CD28 costimulation.

CD8(+) T cells are a critical component of the adaptive immune response against infections and tumors. A current paradigm in immunology is that naive CD8(+) T cells require CD28 costimulation, whereas memory CD8(+) T cells do not. We show here, however, that during viral infections of mice, costimulation is required in vivo for the reactivation of memory CD8(+) T cells. In the absence of CD28 c...

Tissue-Resident Memory CD8+ T Cells: From Phenotype to Function

Tissue-resident memory CD8+ T cells are an important first line of defense from infection in peripheral non-lymphoid tissues, such as the mucosal tissues of the respiratory, digestive, and urogenital tracts. This memory T cell subset is established late during resolution of primary infection of those tissues, has a distinct genetic signature, and is often defined by the cell surface expression ...

An Efficient Method to Solve the Mathematical Model of HIV Infection for CD8+ T-Cells

In this paper, the mathematical model of HIV infection for CD8+ T-cells is illustrated. The homotopy analysis method and the Laplace transformations are combined for solving this model. Also, the convergence theorem is proved to demonstrate the abilities of presented method for solving non-linear mathematical models. The numerical results for $N=5, 10$ are presented. Several $hbar$-c...

Functional differences between memory and naive CD8 T cells.

To determine how murine memory and naive T cells differ, we generated large numbers of long-lived memory CD8(+) T cells and compared them to naive cells expressing the same antigen-specific receptor (T cell receptor; TCR). Although both populations expressed similar levels of TCR and CD8, on antigen stimulation in vitro memory T cells down-regulated their TCR faster and more extensively and sec...